Dog Longevity Pills

LOY-003, the daily longevity pill for large dogs

A daily flavored tablet for dogs aged 5 and over weighing at least 60 lb, working on the same growth pathway as the LOY-001 injection.

Updated

Checked November 2, 2026 against Loyal's updates and the FDA. We look again every week.

What it is

Works on the same growth hormone and IGF-1 pathway as LOY-001, but as a daily pill instead of an injection. Loyal is developing it with Crinetics Pharmaceuticals, a company that makes drugs for hormone disorders in people (Loyal).

Where it stands with the FDA

  1. Effectiveness Sep 16, 2026 The FDA accepted the effectiveness case, Loyal's third. Loyal.
  2. Safety In progress Loyal says safety data is being gathered. Loyal.
  3. Manufacturing Waiting Nothing announced. Loyal.
  4. Conditional approval Waiting Loyal has projected 2027 (said before this drug reached its first step). Loyal.

Its effectiveness case was accepted on September 16, 2026 (Longevity.Technology). Loyal's brief for vets projects conditional approval in 2027, but it was written before this first step (Loyal).

Which dogs it is for

Dogs aged 5 and over weighing at least 60 lb. It reaches big dogs younger than LOY-001 (7 and over) and needs no vet visit to give.

Whether your dog should take any of these is a question for your vet, who knows its health.

Questions people ask

Is LOY-003 approved?

No. The FDA has accepted its effectiveness case, the first of three technical sections, on September 16, 2026. Safety and manufacturing come next, then conditional approval.

Which dogs is LOY-003 for?

Dogs aged 5 and over weighing at least 60 lb, as Loyal describes it.

When could LOY-003 be available?

Loyal has projected conditional approval in 2027 for both of its large dog drugs. No date or price has been announced.

Sources

  1. FDA accepts reasonable expectation of effectiveness for LOY-003, Loyal, September 16, 2026.
  2. Loyal's big dog lifespan drug clears third FDA hurdle, Longevity.Technology, September 22, 2026.
  3. Product brief for veterinarians, version 7, Loyal, read November 2, 2026.