Dog Longevity Pills

The first dog longevity pill has passed two of the FDA's three checks

LOY-002, a daily pill for dogs aged 10 and over weighing at least 14 lb, has FDA sign-off on its effectiveness case and its safety. Its manufacturing is still in progress. It is not approved, and no date or price has been announced.

Checked November 2, 2026 against Loyal's updates and the FDA. We look again every week.

The FDA review, drug by drug

What each step means

LOY-002

2 accepted

Daily pill · dogs 10+ years · 14+ lb

  1. Effectiveness Feb 26, 2025
  2. Safety Jan 13, 2026
  3. Manufacturing In progress
  4. Conditional approval Waiting

LOY-001

1 accepted

Vet injection every 3 to 6 months · dogs 7+ years · 40+ lb

  1. Effectiveness Nov 28, 2023
  2. Safety In progress
  3. Manufacturing Waiting
  4. Conditional approval Waiting

LOY-003

1 accepted

Daily pill · dogs 5+ years · 60+ lb

  1. Effectiveness Sep 16, 2026
  2. Safety In progress
  3. Manufacturing Waiting
  4. Conditional approval Waiting

Which ones is my dog the right age and size for?

A 12-year-old, 30 lb dog is in the age and weight range for LOY-002 only.

Each drug's limits, and the rapamycin trial's

Whether your dog should take any of these is a question for your vet, who knows its health.

Being tested on dogs now

STAY study

LOY-002

LOY-002's STAY study, 1,300 dogs at 72 US vet clinics, enrollment closed, results not before late 2027.

Rapamycin · TRIAD

Recruiting

The Dog Aging Project's rapamycin trial (TRIAD), 580 dogs aged 7+ weighing about 44 to 121 lb, still recruiting, results around 2029.

What it will cost

No price yet.

Loyal's founder has been reported as aiming for under $100 a month (Entrepreneur). More on cost

The longevity chews on sale now

None is FDA approved, and none has shown a longer life in dogs.

  1. Leap Years
  2. Zesty Paws Healthy Aging
  3. ThorneVET Longevity Complex

All 7, and what is in them

What happened, and when

  1. LOY-003's effectiveness case accepted. Loyal.

  2. The STAY study is about two and a half years in. Fortune.

  3. Loyal raises $100M to prepare LOY-002's launch. Loyal.

Every date since 2017