The dog longevity supplements on sale now
Chews with NMN, nicotinamide riboside or senolytics are sold for healthy aging. None is an FDA-approved drug, and none has shown a longer life in dogs.
Dog supplements need no FDA approval before they go on sale, so a "longevity" label tells you what a maker hopes, not what has been shown. The ones below are the best known in the US. We list what is in each and whether any dog study has been published; none has measured lifespan.
| Product | What is in it | Dog studies |
|---|---|---|
| Leap YearsAnimal Biosciences | A soft chew combining a senolytic (meant to clear worn-out cells) with an NAD+ precursor. The maker does not list the exact compounds. Source | One trial, linked to the company: 70 dogs with mild to moderate cognitive decline (Scientific Reports, 2024). Every group improved, placebo included, and the differences were in owner ratings of behavior. Lifespan was not measured. |
| Healthy Aging NAD+ PrecursorZesty Paws, with ChromaDex | Nicotinamide riboside (ChromaDex's Niagen), sold for metabolic health and cell energy. Source | None published that we could find. |
| Longevity ComplexThorneVET | A soft chew of nicotinamide riboside and taurine. Source | None published that we could find. |
| Longevity for DogsFera Pets | NMN with ergothioneine, phosphatidylserine, resveratrol and MCT oil, sold for mitochondrial and brain health. Source | None published that we could find. |
| Longevity and Healthy Aging chewsBoops Pets | Nicotinamide riboside with quercetin and resveratrol. Source | None published that we could find. |
| Dual Action Immunity + LongevityNaturVet | Nicotinamide riboside with immune-support ingredients. Source | None published that we could find. |
| Pet Longevity NMN ChewsProHealth Longevity | NMN in a chicken-flavored chew, $29.95 for 60 at Vitacost when we read it. Source | None published that we could find. |
Why NAD+ and NMN
NAD+ is a molecule cells use to make energy, and its levels fall with age in people and animals. NMN and nicotinamide riboside are building blocks the body turns into it. Studies in mice and early studies in people look at whether topping it up helps; in dogs, the work so far is about behavior and blood levels, not years of life.
How they compare with the drugs
LOY-002 has had its effectiveness case and safety package accepted by the FDA and is in a 1,300-dog trial. No supplement has been through anything like that. If you are thinking about one, take the label to your vet.
Whether your dog should take any of these is a question for your vet, who knows its health.
Sources
- Randomized controlled trial of a senolytic and NAD+ supplement in dogs with cognitive impairment, Scientific Reports, May 29, 2024.
- ChromaDex and Zesty Paws launch a Healthy Aging line for dogs, ChromaDex (via MarketScreener), October 26, 2023.
- Longevity Complex, ThorneVET, read November 2, 2026.
- Fera Pets launches a longevity supplement for dogs, Petfood Industry, 2026.
- Boops Pets Longevity and Healthy Aging chews, Chewy, read November 2, 2026.
- Dual Action Immunity + Longevity soft chews, NaturVet, read November 2, 2026.
- Pet Longevity NMN Chews for dogs, 60 chews, Vitacost, read November 2, 2026.